Pathology of Gastric Intestinal Metaplasia: Clinical Implications

How are we addressing gastric intestinal metaplasia ?

Role of intestinal metaplasia in the histogenesis of gastric carcinoma.

Recent evidence suggests that intestinal metaplasia (IM) cannot be regarded as a single entity. A simple classification of IM and its variants based on histological and mucin histochemical criteria was devised, and the incidence of IM subtypes in cancerous and benign gastrectomy specimens was recorded. A particular subtype was associated with 'intestinal' cancers but not with tumours considered...

Potential role of aquaporin 3 in gastric intestinal metaplasia

Gastric intestinal metaplasia (GIM) is a pre-cancerous condition and a pivotal step in the formation of gastric cancer (GC). Aquaporin 3 (AQP3) has been found to be expressed in goblet cells rather than mucus-secreting glands. To investigate the characteristics of GIM in non-cancerous tissues adjacent to GC, as well as the expression and role of AQP3 in GIM tissues, 16 patients diagnosed with g...

Correlation between Endoscopic and Histological Diagnoses of Gastric Intestinal Metaplasia

BACKGROUND/AIMS Intestinal metaplasia (IM) is a premalignant condition. This study aimed to evaluate the correlation between endoscopic and histological findings of IM. METHODS The cases of IM were graded by conventional endoscopy, and biopsies were taken from the antrum and body of 1,333 subjects for histological IM diagnosis. Multivariate analyses were performed to identify the factors that...

Intestinal metaplasia in endoscopic biopsy specimens of gastric mucosa.

A total of 1412 consecutive cases of endoscopic gastric biopsy, carried out over a four year period, were reviewed and specimens were examined histochemically to determine the prevalence of intestinal metaplasia and its variants. Three types were characterised: complete intestinal metaplasia and two classes of incomplete intestinal metaplasia (type IIa and type IIb) depending on the absence or ...